Ad Blocker Performance on the Desktop has a good write-up about ad blocker performance on the desktop. The best browser extension to use, according to them, is uBlock Origin.

Having used Disconnect, Bluhell Firewall, and other such adblockers, I noticed that uBlock does indeed have very good performance. Although Disconnect does offer a VPN-based ad blocker on iOS, which the others do not.

Read more at the source.